In this paper we introduce an efficient algorithm for alignment of multiple large-scale
biological networks. In this scheme, we first compute a probabilistic similarity measure …

We present a web server for pair-wise alignment of membrane protein sequences, using the
program AlignMe. The server makes available two operational modes of AlignMe:(i) …

Recent advances in evolutionary modelling and alignment methodology mean that today
accurate and fast algorithms exist for aligning sequences with special features and …

Considerable attention has been focused on predicting the secondary structure for aligned
RNA sequences since it is useful not only for improving the limiting accuracy of conventional …

Many DNA sequence analysis tools have been developed to turn the massive raw DNA
sequencing data generated by NGS (Next Generation Sequencing) platforms into …

Multiple sequence alignment (MSA) is a widespread approach in computational biology and
bioinformatics. MSA deals with how the sequences of nucleotides and amino acids are …

Multiple sequence alignment (MSA) constitutes an extremely powerful tool for many
biological applications including phylogenetic tree estimation, secondary structure …

Many estimation problems in bioinformatics are formulated as point estimation problems in a
high-dimensional discrete space. In general, it is difficult to design reliable estimators for this …

This paper proposes a simple and effective approach to improve the accuracy of multiple
sequence alignment. We use a natural measure to estimate the similarity of the input …

Background During procedures for conducting multiple sequence alignment, that is so
essential to use the substitution score of pairwise alignment. To compute adaptive scores for …