Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …

The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the
neuromodulator norepinephrine (NE) in the brain. The LC receives input from widespread …

Prediction errors are differences between expected and actual sensory input and are
thought to be key computational signals that drive learning related plasticity. One way that …

For decades, numerous seminal studies have built our understanding of the locus coeruleus
(LC), the vertebrate brain's principal noradrenergic system. Containing a numerically small …

During spatial learning, hippocampal (HPC) place maps reorganize to represent new goal
locations, but little is known about the circuit mechanisms facilitating these changes. Here …

The locus coeruleus-norepinephrine (LC-NE) system is involved in many brain functions
and neurological disorders. In this review we discuss how LC-NE signaling affects the …

The ability to represent and respond to uncertainty is fundamental to human cognition and
decision-making. Noradrenaline (NA) is hypothesized to play a key role in coordinating the …

Neural dynamics are shaped and constrained by the projections of a small nucleus in the
pons: the noradrenergic locus coeruleus (LC). Much like a bow to the brain's violin, activity in …

Behavioral flexibility is the ability to adjust behavioral strategies in response to changing
environmental contingencies. A major hypothesis in the field posits that the activity of …

Our ability to make sense of the auditory world results from neural processing that begins in
the ear, goes through multiple subcortical areas, and continues in the cortex. The specific …