Background Acacetin is a di-hydroxy and mono-methoxy flavone present in various plants,
including black locust, Damiana, Silver birch. Literature information revealed that acacetin …

Angiogenesis is the development of new blood vessels, which is required for tumor growth
and metastasis. Signal transducer and activator of transcription factor 3 (STAT3) is a …

Background Aberrant activation of STAT3 is frequently encountered and promotes survival,
cellular proliferation, migration, invasion and angiogenesis in tumor cell. Convallatoxin …

Flavonoids are important plant secondary metabolites showing antioxidant, antitumor, anti-
inflammatory, and antiviral activities, among others. Methylated flavonoids are particularly …

Osteoporosis, characterized by the destruction of bone resorption and bone formation, is a
serious disease that endangers human health. Osteoporosis prevention and treatment has …

Breast cancer is one of the top causes of death, particularly among women, and it affects
many women. Cancer can also be caused by various factors, including acquiring genetic …

Cancer chemoprevention is the use of synthetic, natural or biological agents to prevent or
delay the development or progression of malignancies. Intriguingly, many phytochemicals …

Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally
and cause distant metastasis. Adiponectin is a protein hormone secreted predominantly by …

Background Anthracyclines are efficient and potent agents to treat broad range of cancers
but cytotoxicity induced by them limits their use in therapeutics. Use of plant-derived agents …

Chondrosarcomas are a type of primary malignant bone cancer, with a potent capacity for
local invasion and distant metastasis. Brain-derived neurotrophic factor (BDNF) is commonly …