Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke
Despite many years of research, no biomarkers for stroke are available to use in clinical
practice. Progress in high-throughput technologies has provided new opportunities to …
practice. Progress in high-throughput technologies has provided new opportunities to …
Understanding the role of the perivascular space in cerebral small vessel disease
R Brown, H Benveniste, SE Black… - Cardiovascular …, 2018 - academic.oup.com
Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …
Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge
Background The medium-term effects of Coronavirus disease (COVID-19) on organ health,
exercise capacity, cognition, quality of life and mental health are poorly understood …
exercise capacity, cognition, quality of life and mental health are poorly understood …
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …
GWAS on family history of Alzheimer's disease
Alzheimer's disease (AD) is a public health priority for the 21st century. Risk reduction
currently revolves around lifestyle changes with much research trying to elucidate the …
currently revolves around lifestyle changes with much research trying to elucidate the …
White matter hyperintensities are a core feature of Alzheimer's disease: evidence from the dominantly inherited Alzheimer network
Objective White matter hyperintensities (WMHs) are areas of increased signal on T2‐
weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel …
weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel …
Cerebral small vessel disease genomics and its implications across the lifespan
M Sargurupremraj, H Suzuki, X Jian… - Nature …, 2020 - nature.com
White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …
Prevention of stroke in patients with silent cerebrovascular disease: a scientific statement for healthcare professionals from the American Heart Association/American …
Two decades of epidemiological research shows that silent cerebrovascular disease is
common and is associated with future risk for stroke and dementia. It is the most common …
common and is associated with future risk for stroke and dementia. It is the most common …
White matter hyperintensities and imaging patterns of brain ageing in the general population
White matter hyperintensities are associated with increased risk of dementia and cognitive
decline. The current study investigates the relationship between white matter …
decline. The current study investigates the relationship between white matter …
Advances in understanding the pathophysiology of lacunar stroke: a review
RW Regenhardt, AS Das, EH Lo, LR Caplan - JAMA neurology, 2018 - jamanetwork.com
Importance Stroke is the second leading cause of death in the world, and nearly one-third of
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …
ischemic strokes are lacunar strokes (LSs) or small subcortical infarcts. Although smaller in …