COVID-19: attacks the 1-beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism

L Wenzhong, L Hualan - 2020 - chemrxiv.org
The novel coronavirus pneumonia is a contagious acute respiratory disease caused by the
SARS-COV-2 coronavirus. The pathogenic mechanism of the novel coronavirus is unknown …

Holobiont perspectives on tripartite interactions among microbiota, mosquitoes, and pathogens

R Zheng, Q Wang, R Wu, PN Paradkar… - The ISME …, 2023 - academic.oup.com
Mosquito-borne diseases like dengue and malaria cause a significant global health burden.
Unfortunately, current insecticides and environmental control strategies aimed at the vectors …

Arbovirus lifecycle in mosquito: acquisition, propagation and transmission

P Wu, X Yu, P Wang, G Cheng - Expert reviews in molecular …, 2019 - cambridge.org
Mosquitoes are haematophagous vectors for hundreds of pathogenic viruses that are
aetiological agents of human diseases. In nature, mosquito-borne viruses maintain a …

The dose makes the poison: nutritional overload determines the life traits of blood-feeding arthropods

M Sterkel, JHM Oliveira, V Bottino-Rojas… - Trends in …, 2017 - cell.com
Vertebrate blood composition is heavily biased towards proteins, and hemoglobin, which is
a hemeprotein, is by far the most abundant protein. Typically, hematophagous insects ingest …

Advances in research on arboviral acquisition from hosts to mosquitoes

Y Zhu, X Yu, L Jiang, Y Wang, X Shi… - Current Opinion in Insect …, 2024 - Elsevier
Highlights•Host blood components affect mosquito susceptibility to arboviruses in diverse
manners.•The integrity of gut barriers affects the acquisition of viruses from the host's …

Temperature dramatically shapes mosquito gene expression with consequences for mosquito–Zika virus interactions

PG Ferreira, B Tesla, ECA Horácio, LA Nahum… - Frontiers in …, 2020 - frontiersin.org
Vector-borne flaviviruses are emerging threats to human health. For successful
transmission, the virus needs to efficiently enter mosquito cells and replicate within and …

[PDF][PDF] Strong Positive Selection in Aedes aegypti and the Rapid Evolution of Insecticide Resistance

RR Love, JR Sikder, RJ Vivero… - Molecular Biology …, 2023 - academic.oup.com
Aedes aegypti vectors the pathogens that cause dengue, yellow fever, Zika virus, and
chikungunya and is a serious threat to public health in tropical regions. Decades of work has …

Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoes

V Bottino-Rojas, I Ferreira-Almeida, RD Nunes… - Insect biochemistry and …, 2022 - Elsevier
Insect ommochrome biosynthesis pathways metabolize tryptophan to generate eye-color
pigments and wild-type alleles of pathway genes are useful phenotypic markers in …

Catalase protects Aedes aegypti from oxidative stress and increases midgut infection prevalence of Dengue but not Zika

JHM Oliveira, OAC Talyuli… - PLoS neglected …, 2017 - journals.plos.org
Background Digestion of blood in the midgut of Aedes aegypti results in the release of pro-
oxidant molecules that can be toxic to the mosquito. We hypothesized that after a blood …

How micronutrients influence the physiology of mosquitoes

C Rivera-Pérez, ME Clifton, FG Noriega - Current opinion in insect science, 2017 - Elsevier
Highlights•Non-energetic nutrients or micronutrients are essential for mosquito
physiology.•Free amino acids play important roles in digestion, flight physiology and …