The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

In recent years, the disappointing history of translation in pain research has undergone
significant scrutiny. The escalation of knowledge and understanding related to presumed …

The dorsal medial prefrontal cortex (dmPFC) has been recognized as a key cortical area for
nociceptive modulation. However, the underlying neural pathway and the function of specific …

Pain is an unpleasant experience. How the brain's affective neural circuits attribute this
aversive quality to nociceptive information remains unknown. By means of time-lapse in vivo …

Accumulating evidence has shown that complicated brain systems are involved in the
development and maintenance of chronic low back pain (cLBP), but the association …

Neuroimaging of pain in animals allows us to better understand mechanisms of pain
processing and modulation. In this review, we discuss recently published brain imaging …

Imaging awake animals is quickly gaining traction in neuroscience as it offers a means to
eliminate the confounding effects of anesthesia, difficulties of inter-species translation (when …

There are numerous publications on methods and applications for awake functional MRI
across different species, eg, voles, rabbits, cats, dogs, and rhesus macaques. Each of these …

The prevalence of chronic pain has reached epidemic levels. In addition to personal
suffering chronic pain is associated with psychiatric and medical co-morbidities, notably …

Accumulating evidence suggests hippocampal impairment under the chronic pain
phenotype. However, it is unknown whether neuropathic behaviors are related to …