Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

The emerging role of oxidative stress in inflammatory bowel disease

P Muro, L Zhang, S Li, Z Zhao, T Jin, F Mao… - Frontiers in …, 2024 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition that affects the
digestive system and includes Crohn's disease (CD) and ulcerative colitis (UC). Although …

[HTML][HTML] The effect of riboflavin supplementation on the systemic redox status in healthy volunteers: A post-hoc analysis of the RIBOGUT trial

AR Bourgonje, AT Otten, MS Sadabad… - Free Radical Biology …, 2022 - Elsevier
Background Riboflavin is a redox-active vitamin that plays a pivotal role in human energy
metabolism. Riboflavin may have beneficial health effects by increasing extracellular …

[HTML][HTML] Selenium and coenzyme Q10 improve the systemic redox status while reducing cardiovascular mortality in elderly population-based individuals

BJ Dunning, AR Bourgonje, MLC Bulthuis… - Free Radical Biology …, 2023 - Elsevier
Background Serum sulfhydryl groups (R–SH, free thiols) reflect the systemic redox status in
health and disease, and may be amenable to therapeutic modulation. Since R–SH are …

[HTML][HTML] Oxidative stress biomarkers in fetal growth restriction with and without preeclampsia

MH Schoots, MF Bourgonje, AR Bourgonje, JR Prins… - Placenta, 2021 - Elsevier
Introduction Oxidative stress as observed in fetal growth restriction (FGR) and preeclampsia
(PE) can be identified by decreased levels of systemic free thiols (FT) and increased levels …

[HTML][HTML] Serum free sulfhydryl status associates with new-onset chronic kidney disease in the general population

AR Bourgonje, AE Abdulle, MF Bourgonje… - Redox Biology, 2021 - Elsevier
Background Serum sulfhydryl groups (R-SH, free thiols) reliably reflect the systemic redox
status in health and disease. As oxidation of R-SH occurs rapidly by reactive oxygen species …

Systemic oxidative stress associates with new-onset hypertension in the general population

AR Bourgonje, MF Bourgonje, A Post… - Free Radical Biology …, 2022 - Elsevier
Background Oxidative stress is known to be involved in the development of hypertension,
but accurate redox biomarkers predicting the risk of developing hypertension are scarce …

Systemic oxidative stress, aging and the risk of cardiovascular events in the general female population

MF Bourgonje, AR Bourgonje, AE Abdulle… - Frontiers in …, 2021 - frontiersin.org
Introduction: Menopause is associated with increased cardiovascular risk, in which oxidative
stress plays a pivotal role. Systemic oxidative stress is reflected by decreased levels of free …

Adipose Stromal Cell-Derived Secretome Attenuates Cisplatin-Induced Injury In Vitro Surpassing the Intricate Interplay between Proximal Tubular Epithelial Cells and …

E Rendra, S Uhlig, I Moskal, C Thielemann, H Klüter… - Cells, 2024 - mdpi.com
(1) Background: The chemotherapeutic drug cisplatin exerts toxic side effects causing acute
kidney injury. Mesenchymal stromal cells can ameliorate cisplatin-induced kidney injury. We …

Prospective Evaluation of Serum Free Thiols in Inflammatory Bowel Disease: A Candidate to Replace C-Reactive Protein for Disease Activity Assessment?

A Bohra, N Batt, K Dutt, P Sluka… - Inflammatory Bowel …, 2024 - academic.oup.com
Abstract Background Serum free thiols (SFTs) reflecting oxidative stress appear to correlate
with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of …