High mobility group box 1 (HMGB1) is a nonhistone nuclear protein that has multiple
functions according to its subcellular location. In the nucleus, HMGB1 is a DNA chaperone …

The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

Fifty years since the initial discovery of HMGB1 in 1973 as a structural protein of chromatin,
HMGB1 is now known to regulate diverse biological processes depending on its subcellular …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …

Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …

NOD-like receptor (NLR), family pyrin domain containing 3 (NLRP3) assembles a protein
complex known as the NLRP3 inflammasome upon sensing certain pathogen products or …

Pyroptosis has been reported to improve the immunosuppressive tumor microenvironment
and may be a strategy to enhance osteosarcoma treatment. The extent to which modulation …

Pyroptosis is a necrotic form of regulated cell death. Gasdermines (GSDMs) are a family of
intracellular proteins that execute pyroptosis. While GSDMs are expressed as inactive forms …