The glucocorticoid receptor: isoforms, functions, and contribution to glucocorticoid sensitivity
J Lockett, WJ Inder, VL Clifton - Endocrine Reviews, 2024 - academic.oup.com
Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic
homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their …
homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their …
Channel Expansion in the Ligand-Binding Domain of the Glucocorticoid Receptor Contributes to the Activity of Highly Potent Glucocorticoid Analogues
WB Seaton, SJ Burke, AR Fisch, WA Schilletter… - Molecules, 2024 - mdpi.com
Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) and are commonly used
as anti-inflammatory and immunosuppressant medications. Chronic GC use has been linked …
as anti-inflammatory and immunosuppressant medications. Chronic GC use has been linked …
[PDF][PDF] Allosteric Modulation of Glucocorticoid Receptor Activity through Key Interactions within the Ligand Binding Pocket
W Seaton - trace.tennessee.edu
The glucocorticoid receptor (GR) is a transcription factor that influences thousands of genes
throughout the body. Activated by steroidal hormones known as glucocorticoids (GCs), the …
throughout the body. Activated by steroidal hormones known as glucocorticoids (GCs), the …