Purpose To review recent pharmacogenomics studies on breast cancer patients undergoing
tamoxifen therapy, highlighting how our knowledge on cytochrome P450 2D6 (CYP2D6) can …

Warfarin has remained the most commonly prescribed vitamin K oral anticoagulant
worldwide since its approval in 1954. Dosing challenges including having a narrow …

This white paper was prepared by the Global Alliance for Genomics and Health Regulatory
and Ethics Work Stream's Pediatric Task Team to review and provide perspective with …

Purpose: To investigate whether interindividual variability in the CYP2C9 (* 2 and* 3 alleles)
and VKORC1 (rs9923231) genes is associated with increased risk of upper gastrointestinal …

Abstract Background Copy Number variation (CNVs) in genes related to drug absorption,
distribution, metabolism and excretion (ADME) are relevant in the interindividual variability …

Anticoagulant and antiplatelet drugs effectively prevent thrombotic events in patients with
cardiovascular diseases, ischemic stroke, peripheral vascular diseases, and other …

Purpose Fluoropyrimidines are one of the most used drug class to treat cancer patients,
although they show high levels of associated toxicity. This study analyzed 33 polymorphisms …

Pharmacogenetics (PGx) can optimize drug therapy in psychiatry and is particularly
important in admixed populations. Here we developed and successfully validated a …

Therapeutic drug monitoring (TDM) aims to offer assistance to clinicians to improve drug
dosing and clinical outcomes, while minimizing the probability of serious adverse effects in …

Background: Pharmacogenomics (PGx), forming the basis of precision medicine, has
revolutionized traditional medical practice. Currently, drug responses such as drug efficacy …