Auditory dysfunction in schizophrenia: integrating clinical and basic features

DC Javitt, RA Sweet - Nature Reviews Neuroscience, 2015 - nature.com
Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent
psychosocial disability in affected individuals. Although studies of schizophrenia have …

Dendritic spine pathology in schizophrenia

JR Glausier, DA Lewis - Neuroscience, 2013 - Elsevier
Schizophrenia is a neurodevelopmental disorder whose clinical features include
impairments in perception, cognition and motivation. These impairments reflect alterations in …

More than a marker: potential pathogenic functions of MAP2

RA DeGiosio, MJ Grubisha, ML MacDonald… - Frontiers in molecular …, 2022 - frontiersin.org
Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

Neurodevelopment, GABA system dysfunction, and schizophrenia

MJ Schmidt, K Mirnics - Neuropsychopharmacology, 2015 - nature.com
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and
Bleuler began documenting their findings. However, large clinical research efforts in recent …

The neuropathology of schizophrenia: a selective review of past studies and emerging themes in brain structure and cytoarchitecture

K Bakhshi, SA Chance - Neuroscience, 2015 - Elsevier
Schizophrenia is a devastating mental illness. Although its etiology is still largely unknown,
strides have been taken throughout the last several decades to elucidate the nature of the …

Oligodendrocyte development and myelination in neurodevelopment: molecular mechanisms in health and disease

A Barateiro, D Brites… - Current pharmaceutical …, 2016 - ingentaconnect.com
Oligodendrocytes are the myelinating cells of the central nervous system that constitute
about 5 to 10% of the total glial population. These cells are responsible for myelin sheath …

When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits

L Garey - Journal of anatomy, 2010 - Wiley Online Library
Schizophrenia probably has a developmental origin. This review refers to three of our
published series of studies related to this hypothesis: loss of dendritic spines on cerebral …

Loss of microtubule-associated protein 2 immunoreactivity linked to dendritic spine loss in schizophrenia

MA Shelton, JT Newman, H Gu, AR Sampson… - Biological …, 2015 - Elsevier
Background Microtubule-associated protein 2 (MAP2) is a neuronal protein that plays a role
in maintaining dendritic structure through its interaction with microtubules. In schizophrenia …

Targeting glutamate synapses in schizophrenia

JR Field, AG Walker, PJ Conn - Trends in molecular medicine, 2011 - cell.com
Although early clinical observations implicated dopamine dysfunction in the neuropathology
of schizophrenia, accumulating evidence suggests that multiple neurotransmitter pathways …

Neocortical calretinin neurons in primates: increase in proportion and microcircuitry structure

D Džaja, A Hladnik, I Bičanić, M Baković… - Frontiers in …, 2014 - frontiersin.org
In this article we first point at the expansion of associative cortical areas in primates, as well
as at the intrinsic changes in the structure of the cortical column. There is a huge increase in …