From the extracellular matrix to the cytoskeleton, a network of molecular links connects cells
to their environment. Molecules in this network transmit and detect mechanical forces, which …

Water excretion is regulated in large part through the regulation of osmotic water
permeability of the renal collecting duct epithelium. Water permeability is controlled by …

Background & Aims: Smooth muscle is essential for maintaining homeostasis for many body
functions and provides adaptive responses to stresses imposed by pathologic disorders …

The axon initial segment (AIS) is the site of action potential generation and a locus of activity-
dependent homeostatic plasticity. A multimeric complex of sodium channels, linked via a …

Titin, the giant elastic ruler protein of striated muscle sarcomeres, contains a catalytic kinase
domain related to a family of intrasterically regulated protein kinases. The most extensively …

Podosomes are actin-rich adhesion and invasion structures. Especially in macrophages,
podosomes exist in two subpopulations, large precursors at the cell periphery and smaller …

Epithelial to mesenchymal transition (EMT) is a developmental process which is aberrantly
activated during cancer invasion and metastasis. Elevated expression of EMT-inducers like …

Myosin light chain kinase (MLCK) has long been implicated in the myosin phosphorylation
and force generation required for cell migration. Here, we surprisingly found that the deletion …

Intestinal epithelia express two long myosin light-chain kinase (MLCK) splice variants,
MLCK1 and MLCK2, which differ by the absence of a complete immunoglobulin (Ig)-like …

Purpose: To create an in vivo model of PDGFRA D842V-mutant gastrointestinal stromal
tumor (GIST) and identify the mechanism of tumor persistence following avapritinib therapy …