Molecular mechanisms of apoptosis and roles in cancer development and treatment
Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …
Cyclin-dependent kinase pathways as targets for cancer treatment
GI Shapiro - Journal of clinical oncology, 2006 - ascopubs.org
Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins,
drugs mimicking their natural antagonists, BH3-only proteins, might overcome …
drugs mimicking their natural antagonists, BH3-only proteins, might overcome …
Targeting the cell cycle: a new approach to cancer therapy
GK Schwartz, MA Shah - Journal of clinical oncology, 2005 - ascopubs.org
The cell cycle represents a series of tightly integrated events that allow the cell to grow and
proliferate. Critical parts of the cell cycle machinery are the cyclin-dependent kinases …
proliferate. Critical parts of the cell cycle machinery are the cyclin-dependent kinases …
Multiomics profiling establishes the polypharmacology of FDA-approved CDK4/6 inhibitors and the potential for differential clinical activity
The target profiles of many drugs are established early in their development and are not
systematically revisited at the time of FDA approval. Thus, it is often unclear whether …
systematically revisited at the time of FDA approval. Thus, it is often unclear whether …
Targeting the Bcl-2 family for cancer therapy
Introduction: Programmed cell death is well-orchestrated process regulated by multiple pro-
apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family. These genes …
apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family. These genes …
Overview of CDK9 as a target in cancer research
F Morales, A Giordano - Cell Cycle, 2016 - Taylor & Francis
ABSTRACT CDK9 is a protein in constant development in cancer therapy. Herein we
present an overview of the enzyme as a target for cancer therapy. We provide data on its …
present an overview of the enzyme as a target for cancer therapy. We provide data on its …
Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1
D Yecies, NE Carlson, J Deng… - Blood, The Journal of the …, 2010 - ashpublications.org
ABT-737 is a small-molecule antagonist of BCL-2 currently under evaluation in clinical trials
in the oral form of ABT-263. We anticipate that acquired resistance to this promising drug will …
in the oral form of ABT-263. We anticipate that acquired resistance to this promising drug will …
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen …
RR Rosato, JA Almenara, S Grant - Cancer research, 2003 - AACR
Abstract Effects of the histone deacetylase (HDAC) inhibitor MS-275 have been examined in
human leukemia and lymphoma cells (U937, HL-60, K562, and Jurkat) as well as in primary …
human leukemia and lymphoma cells (U937, HL-60, K562, and Jurkat) as well as in primary …
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-xL is an essential survival protein of human myeloma cells
S Derenne, B Monia, NM Dean… - Blood, The Journal …, 2002 - ashpublications.org
Multiple myeloma (MM) is a plasma cell malignancy that occurs mainly in bone marrow. As
MM cells proliferate slowly, it would seem essential to find means of preventing their growth …
MM cells proliferate slowly, it would seem essential to find means of preventing their growth …