Emerging diagnostics and therapeutics for Alzheimer disease

WK Self, DM Holtzman - Nature medicine, 2023 - nature.com
Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …

Blood-based biomarkers for Alzheimer's disease: towards clinical implementation

CE Teunissen, IMW Verberk, EH Thijssen… - The Lancet …, 2022 - thelancet.com
For many years, blood-based biomarkers for Alzheimer's disease seemed unattainable, but
recent results have shown that they could become a reality. Convincing data generated with …

Global estimates on the number of persons across the Alzheimer's disease continuum

A Gustavsson, N Norton, T Fast, L Frölich… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Global estimates on numbers of persons in early stages of Alzheimer's disease
(AD), including prodromal and preclinical, are lacking, yet are needed to inform policy …

Alzheimer's disease

P Scheltens, B De Strooper, M Kivipelto, H Holstege… - The Lancet, 2021 - thelancet.com
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …

Diagnosis of early Alzheimer's disease: clinical practice in 2021

AP Porsteinsson, RS Isaacson, S Knox… - The journal of …, 2021 - Springer
Alzheimer's disease is a progressive, irreversible neurodegenerative disease impacting
cognition, function, and behavior. Alzheimer's disease progresses along a continuum from …

Alzheimer's disease: an update and insights into pathophysiology

MB Abubakar, KO Sanusi, A Ugusman… - Frontiers in aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is an irreversible brain disorder associated with slow, progressive
loss of brain functions mostly in older people. The disease processes start years before the …

Immunotherapy for Alzheimer's disease: Targeting β-amyloid and beyond

C Song, J Shi, P Zhang, Y Zhang, J Xu, L Zhao… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly
worldwide. However, the complexity of AD pathogenesis leads to discrepancies in the …

[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies

JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

The promise of music therapy for Alzheimer's disease: a review

AM Matziorinis, S Koelsch - Annals of the New York Academy of …, 2022 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disease associated with
cognitive decline. Memory problems are typically among the first signs of cognitive …