Background Although the insulin-producing pancreatic β-cells are quite capable of adapting
to both acute and chronic changes in metabolic demand, persistently high demand for …

Mammalian cells take up extracellular material by a variety of different mechanisms that are
collectively termed endocytosis. Endocytic mechanisms serve many important cellular …

The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense interest
because of the potential clinical relevance of this peptide. Produced in intestinal L-cells …

The release of insulin from pancreatic islets requires negative regulation to ensure low
levels of insulin release under resting conditions, as well as positive regulation to facilitate …

OBJECTIVE Pancreatic β-cells exposed to proinflammatory cytokines display alterations in
gene expression resulting in defective insulin secretion and apoptosis. MicroRNAs are small …

OBJECTIVE—Visceral obesity and elevated plasma free fatty acids are predisposing factors
for type 2 diabetes. Chronic exposure to these lipids is detrimental for pancreatic β-cells …

The insulin secretory response by pancreatic β-cells to an acute “square wave” stimulation
by glucose is characterized by a first phase that occurs promptly after exposure to glucose …

It is becoming increasingly apparent that beta cell dysfunction resulting in abnormal insulin
secretion is the essential element in the progression of patients from a state of impaired …

Secretion of the peptide hormone insulin from pancreatic β cells constitutes an important
step in the regulation of body homeostasis. Insulin is stored in large dense core vesicles and …

Septins are GTPases required for the completion of cytokinesis in diverse organisms, yet
their roles in cytokinesis or other cellular processes remain unknown. Here we describe …