Metabolic reprogramming in cancer is not only a biological hallmark but also reveals
treatment vulnerabilities. Numerous metabolic molecules have shown promise as treatment …

Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Pancreatic cancer is an aggressive cancer with a poor prognosis. Metabolic abnormalities
are one of the hallmarks of pancreatic cancer, and pancreatic cancer cells can adapt to …

Most cancer-related deaths among patients with solid tumors are caused by metastases.
Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer …

Although various drug delivery systems that regulated Ca 2+ concentration has been
developed for tumor therapy, their application still presented significant challenges due to …

Iron is an essential element for all organisms. Iron‐containing proteins play critical roles in
cellular functions. The biological importance of iron is largely attributable to its chemical …

Purpose: Temozolomide resistance remains a major obstacle in the treatment of
glioblastoma (GBM). The combination of temozolomide with another agent could offer an …

Iron metabolism dysregulation is tightly associated with cancer development. But the
underlying mechanisms remain poorly understood. Increasing evidence has shown that …

Cancer metastasis poses significant challenges in current clinical therapy. Osthole (OST)
has demonstrated efficacy in treating cervical cancer and inhibiting metastasis. Despite …

Ferroptosis, a type of cell death involving iron and lipid peroxidation, has been found to be
closely associated with the development of many diseases. Mitochondria are vital …