Rationale: Multiple studies have demonstrated an increased risk of chronic obstructive
pulmonary disease (COPD) in heterozygous carriers of the AAT (alpha-1 antitrypsin) Z …

Purpose Many individuals with obstructive airway disease (OAD), including chronic
obstructive pulmonary disease (COPD) and asthma, remain undiagnosed, despite the …

Summary Background Chronic Obstructive Pulmonary Disease (COPD) is a leading cause
of mortality. Predicting mortality risk in patients with COPD can be important for disease …

Vocal cord dysfunction or inducible laryngeal obstructions (VCD/ILO) is a poorly understood,
complex disease of the so-called middle airway. 1 The condition can have a formidable …

Rationale: Subjects with preserved ratio impaired spirometry (PRISm) experience increased
respiratory symptoms, although they present heterogeneous characteristics. However, the …

Subjects with subclinical respiratory dysfunction who do not meet the chronic obstructive
pulmonary disease (COPD) criteria have attracted attention with regard to early COPD …

Purpose A considerable proportion of patients with chronic obstructive pulmonary disease
(COPD) remain undiagnosed and untreated even though they may have a burden of …

Understanding baseline characteristics that can predict the progression of lung disease
such as chronic obstructive pulmonary disease (COPD) for current or former smokers may …

Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome
with phenotypic manifestations that tend to be distributed along a continuum. Unsupervised …

The identified association between a low vital capacity and mortality goes back to the origin
of the spirometer more than 170 years ago. 10 Although a great deal of previous research …