Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …

Aging tissues experience a progressive decline in homeostatic and regenerative capacities,
which has been attributed to degenerative changes in tissue-specific stem cells, stem cell …

Aging is the major risk factor for many human diseases. In vitro studies have demonstrated
that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging …

Telomerase maintains genome stability by extending the 3′ telomeric repeats at eukaryotic
chromosome ends, thereby counterbalancing progressive loss caused by incomplete …

Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …

Cellular senescence describes an irreversible growth arrest characterized by distinct
morphology, gene expression pattern, and secretory phenotype. The final or intermediate …

In mammals, caloric restriction consistently results in extended lifespan. Epigenetic
information encoded by DNA methylation is tightly regulated, but shows a striking drift …

Through an integration of genomic and proteomic approaches to advance understanding of
long noncoding RNAs, we investigate the function of the telomeric transcript, TERRA. By …

Alkaloids are used in traditional medicine for the treatment of many diseases. These
compounds are synthesized in plants as secondary metabolites and have multiple effects on …

Telomere repeats at chromosomal ends, critical to genome integrity, are maintained through
an elaborate network of proteins and pathways. Shelterin complex proteins shield telomeres …