The core of the drug research and screening processes is predicting the effect of drugs prior
to human clinical trials. Due to the 2D cell culture and animal models' poor predictability, the …

Background Species-specific differences in tolerance to infection are exemplified by the high
susceptibility of humans to enterohemorrhagic Escherichia coli (EHEC) infection, whereas …

Acute and chronic respiratory diseases account for major causes of illness and deaths
worldwide. Recent developments of biotherapeutics opened a new era in the treatment and …

Human-to-human transmission of viruses, such as influenza viruses and coronaviruses, can
promote virus evolution and the emergence of new strains with increased potential for …

Human lung function is intricately linked to blood flow and breathing cycles, but it remains
unknown how these dynamic cues shape human airway epithelial biology. Here we report a …

This study describes the characterization of pharmacokinetic (PK) properties of
acetaminophen (APAP) in the Two-Organ-Chip platform (2-OC), a two-chamber device able …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), characterized by its high
fatality rate and contagious nature, has led to significant morbidity and mortality worldwide …

Limitations of the current tools used in the drug development process, cell cultures, and
animal models have highlighted the need for a new powerful tool that can emulate the …

Background Chronic obstructive pulmonary disease (COPD) is a severe public health
problem. Cigarette smoke (CS) is a risk factor for COPD and lung cancer. The underlying …

The absence of in vitro platforms for human pulmonary toxicology studies is becoming an
increasingly serious concern. The respiratory system has a dynamic mechanical structure …