Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Chronic obstructive pulmonary disease (COPD) and lung cancer, closely related to smoking,
are major lung diseases affecting millions of individuals worldwide. The generated gas …

Individuals with type 2 diabetes (T2D) display vascular insulin resistance and decreased
nitric oxide production leading to vasoconstriction and atherosclerosis. Soluble factors such …

Morphea (localized scleroderma) is a rare autoimmune connective tissue disease with
variable clinical presentations, with an annual incidence of 0.4–2.7 cases per 100,000 …

Systemic inflammatory diseases enhance circulating oxidative stress levels, which results in
the oxidation of circulating high-density lipoprotein (oxHDL). Endothelial cell function can be …

Idiopathic pulmonary fibrosis (IPF) is a fatal progressive disease with a median survival of 2–
5 years. Nintedanib is a small tyrosine kinase inhibitor that reduces IPF progression …

Today, cardiovascular diseases remain a leading cause of morbidity and mortality
worldwide. Endothelial to mesenchymal transition (EndMT) does not only play a major role …

Sepsis syndrome develops through enhanced secretion of pro-inflammatory cytokines and
the generation of reactive oxygen species (ROS). Sepsis syndrome is characterized by …

The global targeted disruption of the natriuretic peptide receptor-A (NPRA) gene (Npr1) in
mice provokes hypertension and cardiovascular dysfunction. The objective of this study was …

Background The modification of endothelial cells (ECs) biological function under pathogenic
conditions leads to the expression of mesenchymal stromal cells (MSCs) markers, defined …