Two-pore domain K+(K 2P) channels give rise to leak (also called background) K+ currents.
The well-known role of background K+ currents is to stabilize the negative resting …

The mechanisms through which general anaesthetics, an extremely diverse group of drugs,
cause reversible loss of consciousness have been a long-standing mystery. Gradually, a …

Potassium channels participate in many biological functions, from ion homeostasis to
generation and modulation of the electrical membrane potential. They are involved in a …

It is widely accepted that non-endogenous compounds that target CB1 and/or CB2 receptors
possess therapeutic potential for the clinical management of an ever growing number of …

A distinct gene family of widely distributed and well-modulated two-pore-domain
background potassium (K 2P) channels establish resting membrane potential and cell …

The mammalian family of two-pore domain K+ (K2P) channel proteins are encoded by 15
KCNK genes and subdivided into six subfamilies on the basis of sequence similarities …

TASK1 (KCNK3) and TASK3 (KCNK9) are two‐pore domain potassium channels highly
expressed in adrenal glands. TASK1/TASK3 heterodimers are believed to contribute to the …

General anesthetics depress excitatory and/or enhance inhibitory synaptic transmission
principally by modulating the function of glutamatergic or GABAergic synapses, respectively …

Two-pore domain potassium (K2P) channels stabilize the resting membrane potential of
both excitable and nonexcitable cells and, as such, are important regulators of cell activity …

Central respiratory chemoreception is the mechanism by which the CNS maintains
physiologically appropriate pH and PCO2 via control of breathing. A prominent hypothesis …