Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

The quinoline scaffold is prevalent in a variety of pharmacologically active synthetic and
natural compounds. The discovery of chloroquine, the most famous drug containing this …

Malaria is a disease that affects nearly 40% of the global population, and chemotherapy
remains the mainstay of its control strategy. The global malaria situation is increasingly …

This review summarizes the importance and recent discoveries of the use of adamantane
derivatives in Medicinal Chemistry. We have organized the article in 4 sections: 1) …

Quinoline-containing compounds, such as quinine and chloroquine, have a long-standing
history as potent antimalarial agents. However, the increasing resistance of the Plasmodium …

The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

ABSTRACT According to the World Health Organization, malaria remains one of the biggest
public health problems in the world. The development of resistance is a current concern …

Discovery and development of antimalarial drugs have long been dominated by single-
target therapy. Continuous effort has been made to explore and identify different targets in …

Cyclic peroxides such as the plant-derived 1, 2, 4-trioxane artemisinin and its derivatives are
short-lived, rapidly-acting antimalarials that are now usually combined with standard long …