The myelination of axons has evolved to enable fast and efficient transduction of electrical
signals in the vertebrate nervous system. Acting as an electric insulator, the myelin sheath is …

Progression of Alzheimer's disease (AD) entails deterioration or aberrant function of multiple
brain cell types, eventually leading to neurodegeneration and cognitive decline. Defining …

The integrity of myelinated axons relies on homeostatic support from oligodendrocytes
(OLs). To determine how OLs detect axonal spiking and how rapid axon–OL metabolic …

Myelin is required for rapid nerve signaling and is emerging as a key driver of CNS plasticity
and disease. How myelin is built and remodeled remains a fundamental question of …

Extracellular vesicles (EVs) have recently emerged as versatile elements of cell
communication in the nervous system, mediating tissue homeostasis. EVs influence the …

Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

The functionality of the central nervous system (CNS) relies on the connection, integration,
and the exchange of information among neural cells. The crosstalk among glial cells and …

Alzheimer's disease (AD) remains a leading cause of dementia and poses a heavy burden
on aging populations worldwide (Long and Holtzman, 2019). Amyloid-targeting antibodies …

Abstract Myelin Basic Protein (MBP) is essential for both elaboration and maintenance of
CNS myelin, and its reduced accumulation results in hypomyelination. How different Mbp …

Healthy myelin sheaths consist of multiple compacted membrane layers closely encasing
the underlying axon. The ultrastructure of CNS myelin requires specialized structural myelin …