[HTML][HTML] mTOR as a central regulator of lifespan and aging
The mammalian/mechanistic target of rapamycin (mTOR) is a key component of cellular
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …
metabolism that integrates nutrient sensing with cellular processes that fuel cell growth and …
Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy
JL Carter, K Hege, J Yang, HA Kalpage, Y Su… - Signal transduction and …, 2020 - nature.com
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …
second most common form of acute leukemia in children. Despite this, very little …
[HTML][HTML] Multi-organ proteomic landscape of COVID-19 autopsies
X Nie, L Qian, R Sun, B Huang, X Dong, Q Xiao… - Cell, 2021 - cell.com
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
Targeting AKT/mTOR in oral cancer: mechanisms and advances in clinical trials
Oral cancer (OC) is a devastating disease that takes the lives of lots of people globally every
year. The current spectrum of treatment modalities does not meet the needs of the patients …
year. The current spectrum of treatment modalities does not meet the needs of the patients …
[HTML][HTML] mRNA cap regulation in mammalian cell function and fate
A Galloway, VH Cowling - Biochimica et Biophysica Acta (BBA)-Gene …, 2019 - Elsevier
In this review we explore the regulation of mRNA cap formation and its impact on
mammalian cells. The mRNA cap is a highly methylated modification of the 5′ end of RNA …
mammalian cells. The mRNA cap is a highly methylated modification of the 5′ end of RNA …
Ribosome collisions trigger cis-acting feedback inhibition of translation initiation
Translation of aberrant mRNAs can cause ribosomes to stall, leading to collisions with
trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate …
trailing ribosomes. Collided ribosomes are specifically recognised by ZNF598 to initiate …
Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
Development is tightly connected to aging, but whether pharmacologically targeting
development can extend life remains unknown. Here, we subjected genetically diverse …
development can extend life remains unknown. Here, we subjected genetically diverse …
Ribosomal protein S6: a potential therapeutic target against cancer?
Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …
Eukaryotic translation initiation factors as promising targets in cancer therapy
P Hao, J Yu, R Ward, Y Liu, Q Hao, S An… - Cell Communication and …, 2020 - Springer
The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for
gene expression, and occurs principally at the initiation phase which is mainly regulated by …
gene expression, and occurs principally at the initiation phase which is mainly regulated by …
Regulation of senescence traits by MAPKs
A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular
senescence affects normal aging and age-related disease. Mitogen-activated protein …
senescence affects normal aging and age-related disease. Mitogen-activated protein …