NF-κB, IκB, and IKK: integral components of immune system signaling

MC Mulero, T Huxford, G Ghosh - Structural immunology, 2019 - Springer
Abstract The NF-κB (Nuclear Factor kappa B) transcription factor plays crucial roles in the
regulation of numerous biological processes including development of the immune system …

Sesquiterpenoids lactones: benefits to plants and people

M Chadwick, H Trewin, F Gawthrop… - International journal of …, 2013 - mdpi.com
Sesquiterpenoids, and specifically sesquiterpene lactones from Asteraceae, may play a
highly significant role in human health, both as part of a balanced diet and as …

Targeted degradation of transcription factors by TRAFTACs: transcription factor targeting chimeras

KTG Samarasinghe, S Jaime-Figueroa, M Burgess… - Cell chemical …, 2021 - cell.com
Many diseases, including cancer, stem from aberrant activation or overexpression of
oncoproteins that are associated with multiple signaling pathways. Although proteins with …

The NF-κB family of transcription factors and its regulation

A Oeckinghaus, S Ghosh - Cold Spring Harbor …, 2009 - cshperspectives.cshlp.org
Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in
inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-κB …

NF-κB-mediated neuroinflammation in Parkinson's disease and potential therapeutic effect of polyphenols

SS Singh, SN Rai, H Birla, W Zahra, AS Rathore… - Neurotoxicity …, 2020 - Springer
Different animal and human studies from last two decades in the case of Parkinson's
disease (PD) have concentrated on oxidative stress due to increased inflammation and …

Phosphorylation meets ubiquitination: the control of NF-κB activity

M Karin, Y Ben-Neriah - Annual review of immunology, 2000 - annualreviews.org
NF-κB (nuclear factor-κB) is a collective name for inducible dimeric transcription factors
composed of members of the Rel family of DNA-binding proteins that recognize a common …

Signaling to NF-κB

MS Hayden, S Ghosh - Genes & development, 2004 - genesdev.cshlp.org
The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …

[HTML][HTML] 8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions

X Ba, I Boldogh - Redox biology, 2018 - Elsevier
Oxidative stress and the resulting damage to genomic DNA are inevitable consequences of
endogenous physiological processes, and they are amplified by cellular responses to …

[HTML][HTML] Missing pieces in the NF-κB puzzle

S Ghosh, M Karin - cell, 2002 - cell.com
The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …

Origins of specificity in protein-DNA recognition

R Rohs, X Jin, SM West, R Joshi… - Annual review of …, 2010 - annualreviews.org
Specific interactions between proteins and DNA are fundamental to many biological
processes. In this review, we provide a revised view of protein-DNA interactions that …