Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

The aggregation of proteins into amyloid fibrils and their deposition into plaques and
intracellular inclusions is the hallmark of amyloid disease. The accumulation and deposition …

Nucleation of new peptide and protein aggregates on the surfaces of amyloid fibrils of the
same peptide or protein has emerged in the past two decades as a major pathway for both …

Protein folding involves a large number of steps and conformations in which the folding
protein samples different thermodynamic states characterized by local minima. Kinetically …

Alzheimer's disease (AD) is characterized by a chronic and progressive neurodegenerative
process resulting from the intracellular and extracellular accumulation of fibrillary proteins …

The aggregation of a polypeptide chain into amyloid fibrils and their accumulation and
deposition into insoluble plaques and intracellular inclusions is the hallmark of several …

Huntington's disease is one of several neurodegenerative disorders characterized by the
aggregation of polyglutamine (polyQ)-expanded mutant protein. How polyQ aggregation …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Imbalances in endoplasmic reticulum (ER) proteostasis are associated with etiologically-
diverse degenerative diseases linked to excessive extracellular protein misfolding and …

Secondary nucleation of monomers on the surface of an already existing aggregate that is
formed from the same kind of monomers may lead to autocatalytic amplification of a self …