Steatotic liver disease: pathophysiology and emerging pharmacotherapies

M Kokkorakis, E Muzurović, Š Volčanšek… - Pharmacological …, 2024 - Elsevier
Steatotic liver disease (SLD) displays a dynamic and complex disease phenotype.
Consequently, the metabolic dysfunction-associated steatotic liver disease …

Actions of thyroid hormones and thyromimetics on the liver

RA Sinha, E Bruinstroop, PM Yen - Nature Reviews Gastroenterology & …, 2024 - nature.com
Thyroid hormones (triiodothyronine and thyroxine) are pivotal for metabolic balance in the
liver and entire body. Dysregulation of the hypothalamus–pituitary–thyroid axis can …

Thyroid function, adipokines and mitokines in metabolic dysfunction‐associated steatohepatitis: A multi‐centre biopsy‐based observational study

M Kouvari, L Valenzuela‐Vallejo… - Liver …, 2024 - Wiley Online Library
Abstract Background and Aims Thyroid axis is currently under investigation as a therapeutic
target in metabolic dysfunction‐associated steatotic liver disease (MASLD). Thyroid function …

The interconnection between hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease—the transition from an adipocentric to liver …

M Vesković, N Šutulović, D Hrnčić… - Current issues in …, 2023 - mdpi.com
The central mechanism involved in the pathogenesis of MAFLD is insulin resistance with
hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On …

Autophagy and hepatic lipid metabolism: mechanistic insight and therapeutic potential for MASLD

S Raza, S Rajak, PM Yen, RA Sinha - npj Metabolic Health and Disease, 2024 - nature.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) originates from a
homeostatic imbalance in hepatic lipid metabolism. Increased fat deposition in the liver of …

[HTML][HTML] Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology

P Portincasa, G Baffy - European journal of internal medicine, 2024 - Elsevier
The medical term nonalcoholic fatty liver disease (NAFLD) was coined in 1986 for a
condition that has since become the most prevalent liver disorder worldwide. In the last 3 …

Efficacy and safety of Resmetirom, a selective thyroid hormone receptor-β agonist, in the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD …

R Suvarna, S Shetty, JM Pappachan - Scientific Reports, 2024 - nature.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an important public
health problem owing to its high prevalence and associated morbidity and mortality …

Polyribonucleotide nucleotidyltransferase 1 participates in metabolic-associated fatty liver disease pathogenesis by affecting lipid metabolism and mitochondrial …

C Guan, X Zou, C Yang, W Shi, J Gao, Y Ge, Z Xu… - Molecular …, 2024 - Elsevier
Objective Metabolic-associated fatty liver disease (MAFLD) represents one of the most
prevalent chronic liver conditions worldwide, but its precise pathogenesis remains unclear …

Metabolic Dysfunction-Associated Steatotic Liver Disease and Polycystic Ovary Syndrome: A Complex Interplay

K Arvanitakis, E Chatzikalil, G Kalopitas… - Journal of Clinical …, 2024 - pmc.ncbi.nlm.nih.gov
Metabolic dysfunction-associated steatotic liver disease (MASLD) and polycystic ovary
syndrome (PCOS) are prevalent conditions that have been correlated with infertility through …

[HTML][HTML] Hepatokines and MASLD: The GLP1-Ras-FGF21-Fetuin-A Crosstalk as a Therapeutic Target

I Milani, M Codini, G Guarisco, M Chinucci… - International Journal of …, 2024 - mdpi.com
The introduction of the term “Metabolic Steatotic Liver Disease”(MASLD) underscores the
critical role of metabolic dysfunction in the development and progression of chronic liver …