Bacterial survival requires an intact peptidoglycan layer, a three-dimensional exoskeleton
that encapsulates the cytoplasmic membrane. Historically, the final steps of peptidoglycan …

Peptidoglycan, the exoskeleton of bacterial cell and an essential barrier that protects the
cell, is synthesized by a pathway where the final steps are catalysed by transpeptidases …

Despite the advances in tuberculosis treatment, TB is still one the most deadly infectious
diseases and remains a major global health quandary. Mycobacterium tuberculosis (Mtb) is …

The peptidoglycan biosynthesis pathway plays a vital role in bacterial cells, and facilitates
peptidoglycan layer formation, a fundamental structural component of the bacterial cell wall …

Virtual screening is a useful in silico approach to identify potential leads against various
targets. It is known that carbapenems (doripenem and faropenem) do not show any …

RpfB is multidomain protein that is crucial for Mycobacterium tuberculosis resuscitation from
dormancy. This protein cleaves cell wall peptidoglycan, an essential bacterial cell wall …

The study of proteins and mechanisms involved in the apoptosis and new knowledge about
cancer's biology are essential for planning new drugs. Tumor cells develop several …

Tuberculosis (TB) is one of the world's deadliest diseases resulting from infection by the
bacterium, Mycobacterium tuberculosis (M. tb). The L, D-transpeptidase enzymes catalyze …

L, D-transpeptidases, widely distributed in bacteria and even in the difficult-to-treat ESKAPE
pathogens, can confer antibacterial resistance against the traditional β-lactam antibiotics …

Tuberculosis remains a dreadful disease that has claimed many human lives worldwide and
elimination of the causative agent Mycobacterium tuberculosis also remains elusive …