Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism
S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …
several diseases are discussed here. Pure human BChE has been proved safe and effective …
Ghrelin as a survival hormone
Ghrelin administration induces food intake and body weight gain. Based on these actions,
the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using …
the ghrelin system was initially proposed as an antiobesity target. Subsequent studies using …
GDF-15 neutralization alleviates platinum-based chemotherapy-induced emesis, anorexia, and weight loss in mice and nonhuman primates
Platinum-based cancer therapy is restricted by dose-limiting side effects and is associated
with elevation of growth differentiation factor 15 (GDF-15). But whether this elevation …
with elevation of growth differentiation factor 15 (GDF-15). But whether this elevation …
Cholinesterases and the fine line between poison and remedy
CN Pope, S Brimijoin - Biochemical pharmacology, 2018 - Elsevier
Abstract Acetylcholinesterase (AChE, EC 3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1.
1.8) are related enzymes found across the animal kingdom. The critical role of …
1.8) are related enzymes found across the animal kingdom. The critical role of …
Ghrelin's relationship to blood glucose
Much effort has been directed at studying the orexigenic actions of administered ghrelin and
the potential effects of the endogenous ghrelin system on food intake, food reward, body …
the potential effects of the endogenous ghrelin system on food intake, food reward, body …
Circulating acyl and des-acyl ghrelin levels in obese adults: a systematic review and meta-analysis
Y Wang, Q Wu, Q Zhou, Y Chen, X Lei, Y Chen… - Scientific reports, 2022 - nature.com
Ghrelin is the only known orexigenic gut hormone, and its synthesis, secretion and
degradation are affected by different metabolic statuses. This meta-analysis aimed to …
degradation are affected by different metabolic statuses. This meta-analysis aimed to …
Optical imaging probes for selective detection of butyrylcholinesterase
Butyrylcholinesterase (BChE), a member of the human serine hydrolase family, is an
essential enzyme for cholinergic neurotransmission as it catalyzes the hydrolysis of …
essential enzyme for cholinergic neurotransmission as it catalyzes the hydrolysis of …
Ghrelin signaling: GOAT and GHS-R1a take a LEAP in complexity
A Abizaid, JL Hougland - Trends in Endocrinology & Metabolism, 2020 - cell.com
Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets
for disorders related to energy balance and metabolic regulation. Pharmacological control of …
for disorders related to energy balance and metabolic regulation. Pharmacological control of …
Coronary heart disease in type 2 diabetes mellitus: genetic factors and their mechanisms, gene-gene, and gene-environment interactions in the asian populations
KA Zarkasi, NA Abdul Murad, N Ahmad… - International Journal of …, 2022 - mdpi.com
Asians are more susceptible to type 2 diabetes mellitus (T2D) and its coronary heart disease
(CHD) complications than the Western populations, possibly due to genetic factors, higher …
(CHD) complications than the Western populations, possibly due to genetic factors, higher …
[HTML][HTML] A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes
Background The hormone ghrelin stimulates food intake, promotes adiposity, increases
body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels …
body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels …