Revisiting lab-on-a-chip technology for drug discovery

P Neužil, S Giselbrecht, K Länge, TJ Huang… - Nature reviews Drug …, 2012 - nature.com
The field of microfluidics or lab-on-a-chip technology aims to improve and extend the
possibilities of bioassays, cell biology and biomedical research based on the idea of …

Organ-on-a-chip technology: an in-depth review of recent advancements and future of whole body-on-chip

R Driver, S Mishra - BioChip Journal, 2023 - Springer
One of the leading challenges facing the pharmaceutical industry today is the 'high attrition
rate problem', with a large number of drug candidates being abandoned before reaching the …

Latest developments in micro total analysis systems

A Arora, G Simone, GB Salieb-Beugelaar… - Analytical …, 2010 - ACS Publications
The field of micro total analysis systems (μTAS)(1) or lab on a chip (LOC) has extended its
usefulness into many new fields and disciplines spanning basic research to commercial …

Spatial control of cell adhesion and patterning through mussel-inspired surface modification by polydopamine

SH Ku, JS Lee, CB Park - Langmuir, 2010 - ACS Publications
The spatial control and patterning of mammalian cells were achieved by using the universal
adhesive property of mussel-inspired polydopamine (PDA). The self-polymerization of …

In vitro models and systems for evaluating the dynamics of drug delivery to the healthy and diseased brain

HP Modarres, M Janmaleki, M Novin, J Saliba… - Journal of Controlled …, 2018 - Elsevier
The blood-brain barrier (BBB) plays a crucial role in maintaining brain homeostasis and
transport of drugs to the brain. The conventional animal and Transwell BBB models along …

Amyloid-like self-assembly of a hydrophobic cell-penetrating peptide and its use as a carrier for nucleic acids

LR de Mello, L Porosk, TC Lourenço… - ACS Applied Bio …, 2021 - ACS Publications
Cell-penetrating peptides (CPPs) are a topical subject potentially exploitable for creating
nanotherapeutics for the delivery of bioactive loads. These compounds are often classified …

Advanced Human BBB‐on‐a‐Chip: A New Platform for Alzheimer's Disease Studies

JK Yoon, J Kim, Z Shah, A Awasthi… - Advanced …, 2021 - Wiley Online Library
The blood− brain barrier (BBB) is a unique vascular structure that serves as a molecular
transport gateway for the maintenance of brain homeostasis. Chronic disruption or …

Microfluidic Brain‐on‐a‐Chip: From Key Technology to System Integration and Application

Z Wang, Y Zhang, Z Li, H Wang, N Li, Y Deng - Small, 2023 - Wiley Online Library
As an ideal in vitro model, brain‐on‐chip (BoC) is an important tool to comprehensively
elucidate brain characteristics. However, the in vitro model for the definition scope of BoC …

Electrochemical immunosensors for effective evaluation of amyloid-beta modulators on oligomeric and fibrillar aggregation processes

AJ Veloso, AM Chow, HVS Ganesh, N Li… - Analytical …, 2014 - ACS Publications
A novel electrochemical immunosensor fabricated from gold compact disc electrodes was
designed for rapid evaluation of aggregation processes that lead to the formation of …

Trace copper (II) or zinc (II) ions drastically modify the aggregation behavior of amyloid-β 1–42: An AFM study

M Innocenti, E Salvietti, M Guidotti… - Journal of …, 2010 - content.iospress.com
Formation of amyloid-β (Aβ) 1–42 amyloid fibrils, a characteristic feature of Alzheimer's
disease (AD), was monitored in situ through atomic force microscopy (AFM). Well-structured …