In vivo multiplexed bioimaging in the second near-infrared window (NIR-II, 1000–1700 nm),
owing to its superiorities of simultaneous multi-channel (multicolor) observations for multiple …

Cells employ a plethora of signaling pathways to make their life-and-death decisions.
Extensive genetic, biochemical, and physiological studies have led to the accumulation of …

The Arabidopsis photoreceptor cryptochrome 2 (CRY2) was previously used as an
optogenetic module, allowing spatiotemporal control of cellular processes with light. Here …

Fluorescence imaging multiplicity of biological systems is an area of intense focus, currently
limited to fluorescence channels in the visible and first near-infrared (NIR-I;∼ 700–900 nm) …

Arabidopsis thaliana cryptochrome 2 (At CRY2), a light-sensitive photosensory protein, was
previously adapted for use in controlling protein–protein interactions through light …

Our knowledge of the brain has evolved over millennia in philosophical, experimental and
theoretical phases. We suggest that the next phase is simulation neuroscience. The main …

One goal of systems neuroscience is a structure-function model of nervous system
organization that would allow mechanistic linking of mind, brain, and behavior. A necessary …

Genome engineering techniques represented by the Cre–loxP recombination system have
been used extensively for biomedical research. However, powerful and useful techniques …

Tyrosine-type site-specific recombinases (T-SSRs) have opened new avenues for the
predictable modification of genomes as they enable precise genome editing in heterologous …

Brainbow is a genetic cell-labeling technique where hundreds of different hues can be
generated by stochastic and combinatorial expression of a few spectrally distinct fluorescent …