[HTML][HTML] Oxindole and its derivatives: A review on recent progress in biological activities
YM Khetmalis, M Shivani, S Murugesan… - Biomedicine & …, 2021 - Elsevier
Oxindole has been shown to be a pharmacologically advantageous scaffold having many
biological properties that are relevant to medicinal chemistry. The simplicity and widespread …
biological properties that are relevant to medicinal chemistry. The simplicity and widespread …
A mini review on isatin, an anticancer scaffold with potential activities against neglected tropical diseases (NTDs)
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …
therapeutic fragments in drug design and development. The template has turned out to be …
Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents
In recent years, cell cycle and checkpoint pathways regulation are offering new therapeutic
approaches against cancer. Isatin, is a well exploited scaffold in the anticancer domain …
approaches against cancer. Isatin, is a well exploited scaffold in the anticancer domain …
Isatin thiazoles as antidiabetic: Synthesis, in vitro enzyme inhibitory activities, kinetics, and in silico studies
Diabetes mellitus is one of the most prevalent diseases nowadays. Several marketed drugs
are available for the cure and treatment of diabetes, but there is still a dire need of …
are available for the cure and treatment of diabetes, but there is still a dire need of …
Advances in synthesis, derivatization and bioactivity of isatin: a review
Background: Isatin (IST) is a crucial pharmacologically active compound, chemically known
as indole-1H-2, 3-dione. Development of different IST based analogues acquired significant …
as indole-1H-2, 3-dione. Development of different IST based analogues acquired significant …
Synthesis, characterization, thermal, DFT study, antioxidant and antimicrobial in vitro investigations of indazole and its Ag (I) complex
In this study, experimental and computational analyses were performed on free indazole
and its silver metal complex. By using spectral methods, thermal studies, and analytical …
and its silver metal complex. By using spectral methods, thermal studies, and analytical …
Novel (2-Oxoindolin-3-ylidene) methyl)-1H-pyrazole and their fused derivatives: Design, synthesis, antimicrobial evaluation, DFT, chemical approach, in silico ADME …
A series of novel (2-oxoindolin-3-ylidene) methyl)-1H-pyrazole and their fused derivatives
bearing oxindole moiety have been designed and successfully synthesized to and …
bearing oxindole moiety have been designed and successfully synthesized to and …
Design and synthesis of novel 2, 4, 5-thiazole derivatives as 6-APA mimics and antimicrobial activity evaluation
Nine new thiazole derivatives were synthesized considering 6-acetyl penicillanic acid (6-
APA) and investigated for their antimicrobial activity. Ethyl 2-(2-mercaptoacetamido)-4 …
APA) and investigated for their antimicrobial activity. Ethyl 2-(2-mercaptoacetamido)-4 …
New indole and indazole derivatives as potential antimycobacterial agents
VT Angelova, T Pencheva, N Vassilev… - Medicinal Chemistry …, 2019 - Springer
The study reports on the synthesis and in vitro assessment of the antimycobacterial activity
of a series of new indole-and indazole-based aroylhydrazones evaluated against …
of a series of new indole-and indazole-based aroylhydrazones evaluated against …
In-vitro evaluation of isatin derivatives as potent anti-breast cancer agents against MCF-7, MDA MB 231, MDA-MB 435 and MDA-MB 468 breast cancers cell lines: a …
Introduction: Breast cancer (BC) is one of the most frequent malignancies and the most
common reasons for impermanence in women. The backbone of therapy for BC is …
common reasons for impermanence in women. The backbone of therapy for BC is …