Early life stress (ELS) causes long-lasting changes in brain plasticity induced by the
exposure to stress factors acting prenatally or in the early postnatal ontogenesis due to …

There are many 'faces' of early life adversity (ELA), such as childhood trauma,
institutionalisation, abuse or exposure to environmental toxins. These have been implicated …

Background Sinisan (SNS) consists of four kinds of herbs, which is the core of
antidepressant prescription widely used in traditional Chinese medicine clinic treatment for …

Preclinical evidence suggests that antidepressants (ADs) may differentially influence
mitochondrial energetics. This study was conducted to investigate the relationship between …

Exposure to early-life stress (ES) increases the vulnerability to develop metabolic diseases
as well as cognitive dysfunction, but the specific biological underpinning of the ES-induced …

Objective: Early-life adversity (ELA) is one of the strongest predictors of childhood
depression that may be exacerbated by a genetic predisposition to develop depression. We …

Background The epigenetic study of childhood trauma has become a valuable field.
However, the evolution and emerging trends in epigenetics and childhood trauma have not …

Background Irritable bowel syndrome (IBS) is one of the most common functional
gastrointestinal disorder. Traditionally, early life stress (ELS) is predisposed to IBS in adult …

Social stress experienced in childhood is associated with adverse health later in life.
Mitochondrial function has been implicated as a mechanism for how stressful life events “get …

Background Efforts to improve treatment for adults with major depression (MD) and
childhood maltreatment (CM) have identified inflammation as a potential target to improve …