Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites
B Schmidt, B Schieffer - Journal of medicinal chemistry, 2003 - ACS Publications
The renin angiotensin system (RAS) is one of the most powerful regulators of blood pressure
and volume homeostasis in mammals. Its effector peptide angiotensin II (ANG II) is cleaved …
and volume homeostasis in mammals. Its effector peptide angiotensin II (ANG II) is cleaved …
[PDF][PDF] A review on candesartan: pharmacological and pharmaceutical profile
A Husain, MS Azim, M Mitra… - Journal of Applied …, 2011 - japsonline.com
Candesartan is classified as an angiotensin II receptor type 1 antagonist. Angiotensin II
receptor type 1 antagonists are widely used in treatment of diseases like hypertension, heart …
receptor type 1 antagonists are widely used in treatment of diseases like hypertension, heart …
Efficiency of ozonation and O3/H2O2 as enhanced wastewater treatment processes for micropollutant abatement and disinfection with minimized byproduct formation
Ozonation, a viable option for improving wastewater effluent quality, requires process
optimization to ensure the organic micropollutants (OMPs) elimination and disinfection …
optimization to ensure the organic micropollutants (OMPs) elimination and disinfection …
In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: application of the mechanistic absorption model GI-Sim
E Sjögren, J Westergren, I Grant, G Hanisch… - European journal of …, 2013 - Elsevier
Oral drug delivery is the predominant administration route for a major part of the
pharmaceutical products used worldwide. Further understanding and improvement of …
pharmaceutical products used worldwide. Further understanding and improvement of …
Fast screening method for the determination of angiotensin II receptor antagonists in human plasma by high-performance liquid chromatography with fluorimetric …
L Gonzalez, JA Lopez, RM Alonso… - Journal of Chromatography …, 2002 - Elsevier
A selective, accurate and precise high-performance liquid chromatographic assay coupled
to fluorescence detection was developed for the detection of some angiotensin II receptor …
to fluorescence detection was developed for the detection of some angiotensin II receptor …
Modulation of microenvironmental pH and crystallinity of ionizable telmisartan using alkalizers in solid dispersions for controlled release
The present work is an original evaluation of the microenvironmental pH (pHM) and
crystallinity of an ionizable drug in order to enhance its dissolution using alkalizers in …
crystallinity of an ionizable drug in order to enhance its dissolution using alkalizers in …
Tautomerism in drug discovery
AR Katritzky, CD Hall, BEDM El-Gendy… - Journal of Computer …, 2010 - Springer
The influence of tautomerism on the precise structure of drugs and thus of their potential to
interact with biological systems is discussed from thermodynamic and kinetic aspects. The …
interact with biological systems is discussed from thermodynamic and kinetic aspects. The …
[HTML][HTML] Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles
High performance liquid chromatographic method was optimized, developed and validated
as per the ICH guidelines. In this study the 20 mM ammonium formate and acetonitrile in the …
as per the ICH guidelines. In this study the 20 mM ammonium formate and acetonitrile in the …
Critical analysis and optimization of stoichiometric ratio of drug-coformer on cocrystal design: molecular docking, in vitro and in vivo assessment
In this present research, an attempt has been made to address the influence of drug-
coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility …
coformer stoichiometric ratio on cocrystal design and its impact on improvement of solubility …
Biocompatible in-tube solid-phase microextraction coupled to HPLC for the determination of angiotensin II receptor antagonists in human plasma and urine
J Nie, M Zhang, Y Fan, Y Wen, B Xiang… - … of chromatography B, 2005 - Elsevier
A poly (methacrylic acid-ethylene glycol dimethacrylate, MAA-EGDMA) monolithic capillary
was used for the in-tube solid-phase microextraction (in-tube SPME) of several angiotensin …
was used for the in-tube solid-phase microextraction (in-tube SPME) of several angiotensin …