Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

While the peptide and protein therapeutic market has developed significantly in the past
decades, delivery has limited their use. Although oral delivery is preferred, most are …

Glioma treatment using targeted chemotherapy is still far from satisfactory due to not only the
limited accumulation but also the multiple survival mechanisms of glioma cells, including up …

The last years have seen a steady increase in our understanding of legumain biology that is
driven from two largely uncoupled research arenas, the mammalian and the plant legumain …

The age-dependent deposition of amyloid-β peptides, derived from amyloid precursor
protein (APP), is a neuropathological hallmark of Alzheimer's disease (AD). Despite age …

The tumor microenvironment plays a critical role in tumor initiation, progression, metastasis,
and resistance to therapy. It is different from normal tissue in the extracellular matrix …

Cyclotides are diverse plant backbone cyclized peptides that have attracted interest as
pharmaceutical scaffolds, but fundamentals of their biosynthetic origin remain elusive …

Breaking and forming peptidyl bonds are fundamental biochemical reactions in protein
chemistry. Unlike proteases that are abundantly available, fast-acting ligases are rare …

Tumor-associated macrophages (TAMs) are associated with tumor progression and
metastasis. Here, we demonstrate for the first time that legumain, a member of the …

A cellular feature of Parkinson's disease is cytosolic accumulation and amyloid formation of
α-synuclein (α-syn), implicating a misregulation or impairment of protein degradation …