Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

There is a close relationship between Alzheimer's disease (AD) and diabetes mellitus (DM),
and the link between the two is often referred to as type 3 diabetes mellitus (T3DM). Many …

Background Autophagic flux is coordinated by a network of master regulatory genes, which
centered on transcription factor EB (TFEB). The disorders of autophagic flux are closely …

Simple Summary Tau is an important protein for maintaining the shape and normal function
of nerve cells. There are many diseases that are identified by changes in this protein, yet …

Background Alzheimer's disease (AD) is a complicated and refractory neurodegenerative
disease that is typically characterized by memory loss and multiple cognitive impairments …

Neuropathic pain (NP) is a prevalent clinical problem for which satisfactory treatment options
are unavailable. Tetrandrine (TET), a bisbenzylisoquinoline alkaloid extracted from …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and affects
millions of individuals globally. AD is associated with cognitive decline and memory loss that …

Pulmonary fibrosis is a chronic and progressive disease, current systemic administration is
not fully effective with many side effects, such as gastrointestinal and liver injury. The …

Abstract Background In recent years, Salvia miltiorrhiza and its active substances have
remarkably progressed in treating central neurological disorders. Tanshinone IIA (TSA) is an …

Background: Autophagy is a conserved physiological intracellular mechanism responsible
for the degradation and recycling of cytoplasmic constituents (eg, damaged organelles, and …