For decades, insight into fundamental principles of human biology and disease has been
obtained primarily by experiments in animal models. While this has allowed researchers to …

Central to the core principle of cell theory, depicting cells' history, state and fate is a
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …

The formation of transcription regulatory complexes by the association of Smad4 with
Smad2 and Smad3 (Smad2/3) is crucial in the canonical TGFβ pathway. Although the …

Single-cell sequencing is a powerful approach that can detect genetic alterations and their
phenotypic consequences in the context of human development, with cellular resolution …

Detailed characterization of cell type transitions is essential for cell biology in general and
particularly for the development of stem cell-based therapies in regenerative medicine. To …

As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early
mammalian development, they acquire high DNA methylation levels. During this transition …

Abstract Di (2-ethylhexyl) phthalate (DEHP) early exposure leads to immature testicular
injury, and we aimed to utilize single-cell RNA (scRNA) sequencing to comprehensively …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …

Cell cycle and differentiation decisions are linked; however, the underlying principles that
drive these decisions are unclear. Here, we combined cell-cycle reporter system and single …

Single-cell research has provided a breakthrough in biology to understand heterogeneous
cell groups, such as tissues and organs, in development and disease. Molecular barcoding …