Cancer is one of the leading causes of death, and despite increased research in recent
years, control of advanced-stage disease and optimal therapeutic responses remain elusive …

Many cancers possess an incorrect number of chromosomes, a state described as
aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of …

Chromosome instability (CIN) is gaining increasing interest as a central process in cancer.
CIN, either past or present, is indicated whenever tumour cells harbour an abnormal quantity …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …

The most important prognostic variables of cervical carcinoma are FIGO stage, lymph node
status and clinical-pathological features of primary tumor. Recently, there has been …

One form of chromosome instability (CIN), the recurrent missegregation of whole
chromosomes during cell division (W-CIN), leads to aneuploidy. Although W-CIN is a …

Polo-like kinases (PLKs) belong to a five-membered family of highly conserved
serine/threonine kinases (PLK1-5) that play differentiated and essential roles as key mitotic …

Aneuploidy is a common feature of cancer cells, and is believed to play a critical role in
tumorigenesis and cancer progression. Most cancer cells also exhibit high rates of mitotic …

Aneuploidy is widely acknowledged as a leading cause of miscarriage and birth defects in
humans, and is generally known to be deleterious to the survival of individual cells …

Background: DNA ploidy analysis involves automated quantification of chromosomal
aneuploidy, a potential marker of progression toward cervical carcinoma. We evaluated the …