Plant mitochondria have a complex and peculiar genetic system. They have the largest
genomes, as compared to organelles from other eukaryotic organisms. These can expand …

Mitochondria are regarded as the metabolic centers of cells and are integral in many other
cell processes, including the immune response. Each mitochondrion contains numerous …

It is well-known that mitochondrial DNA (mtDNA) can escape to intracellular or extracellular
compartments under different stress conditions, yet understanding their escape mechanisms …

Mitochondrial dysfunctions play major roles in many diseases. However, how mitochondrial
stresses are relayed to downstream responses remains unclear. Here we show that the RNA …

Therapies for genetic disorders caused by mutated mitochondrial DNA are an unmet need,
in large part due barriers in delivering DNA to the organelle and the absence of relevant …

Gene delivery targeting mitochondria has the potential to transform the therapeutic
landscape of mitochondrial genetic diseases. Taking advantage of the nonuniversal genetic …

Mitochondria possess transport mechanisms for import of RNA and DNA. Based on import
into isolated Solanum tuberosum mitochondria in the presence of competitors, inhibitors or …

Mitochondria have retained indispensable but limited genetic information and they import
both proteins and nucleic acids from the cytosol. RNA import is essential for gene …

Many mitochondrial genes have been transferred to the nucleus in course of evolution. The
products of expression of these genes, being still necessary for organelle function, are …

In plants, the voltage-dependent anion-selective channel (VDAC) is a major component of a
pathway involved in transfer RNA (tRNA) translocation through the mitochondrial outer …