This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Piezo1 and Piezo2 are mechanically activated ion channels that mediate touch perception,
proprioception and vascular development. Piezo proteins are distinct from other ion …

Mechanotransduction couples mechanical stimulation with ion flux, which is critical for
normal biological processes involved in neuronal cell development, pain sensation, and red …

OSCA/TMEM63s form mechanically activated (MA) ion channels in plants and animals,
respectively. OSCAs and related TMEM16s and transmembrane channel-like (TMC) …

Cellular mechanotransduction, the process of translating mechanical forces into biological
signals, is crucial for a wide range of physiological processes. A role for ion channels in …

Iron overload causes progressive organ damage and is associated with arthritis, liver
damage, and heart failure. Elevated iron levels are present in 1%–5% of individuals; …

In 2010, two proteins, Piezo1 and Piezo2, were identified as the long-sought molecular
carriers of an excitatory mechanically activated current found in many cells. This discovery …

Mechanotransduction, the conversion of physical forces into biochemical signals, is
essential for various physiological processes such as the conscious sensations of touch and …

The evolutionarily conserved Piezo channel family, including Piezo1 and Piezo2 in
mammals, serves as versatile mechanotransducers in various cell types and consequently …