Telomere length in epidemiology: a biomarker of aging, age-related disease, both, or neither?

JL Sanders, AB Newman - Epidemiologic reviews, 2013 - academic.oup.com
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and
oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during …

Progression of Early Subclinical Atherosclerosis (PESA) Study: JACC Focus Seminar 7/8

B Ibanez, A Fernández-Ortiz, L Fernández-Friera… - Journal of the American …, 2021 - jacc.org
Atherosclerosis starts early in life and progresses silently for decades. Considering
atherosclerosis as a “systemic disease” invites the use of noninvasive methodologies to …

[HTML][HTML] Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies

M Gielen, GJ Hageman, EE Antoniou, K Nordfjall… - The American journal of …, 2018 - Elsevier
Background Even before the onset of age-related diseases, obesity might be a contributing
factor to the cumulative burden of oxidative stress and chronic inflammation throughout the …

Cellular aging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk

P Willeit, J Willeit, A Brandstätter… - … , and vascular biology, 2010 - Am Heart Assoc
Objective—To determine the association between leukocyte telomere length (TL) and
atherosclerosis and its clinical sequelae stroke and myocardial infarction. Methods and …

[HTML][HTML] Telomere length: a cardiovascular biomarker and a novel therapeutic target

M Sagris, P Theofilis, AS Antonopoulos… - International Journal of …, 2022 - mdpi.com
Coronary artery disease (CAD) is a multifactorial disease with a high prevalence, particularly
in developing countries. Currently, the investigation of telomeres as a potential tool for the …

Telomere Length as Cardiovascular Aging Biomarker: JACC Review Topic of the Week

T De Meyer, T Nawrot, S Bekaert… - Journal of the American …, 2018 - jacc.org
Telomeres shorten with age, the major risk factor for atherosclerotic cardiovascular disease
(aCVD). The observation of shorter telomeres in aCVD patients thus suggested that critical …

Short telomere load, telomere length, and subclinical atherosclerosis: the PESA study

JM Fernández-Alvira, V Fuster, B Dorado… - Journal of the American …, 2016 - jacc.org
Background: Leucocyte telomere length (LTL) shortening is associated with cardiovascular
ischemic events and mortality in humans, but data on its association with subclinical …

[HTML][HTML] Telomere length: implications for atherogenesis

H Yin, JG Pickering - Current Atherosclerosis Reports, 2023 - Springer
Abstract Purpose of Review The purpose of the study is to explore the evidence linking
telomere length with atherosclerotic ischemic disease. Recent Findings There has been a …

Short telomeres, but not telomere attrition rates, are associated with carotid atherosclerosis

S Toupance, C Labat, M Temmar, P Rossignol… - …, 2017 - Am Heart Assoc
Short telomeres are associated with atherosclerosis. However, the temporal relationship
between atherosclerosis and telomere length is unclear. The objective of this work was to …

[HTML][HTML] Telomeres, aging and exercise: guilty by association?

W Chilton, B O'Brien, F Charchar - International journal of molecular …, 2017 - mdpi.com
Telomeres are repetitive tandem DNA sequences that cap chromosomal ends protecting
genomic DNA from enzymatic degradation. Telomeres progressively shorten with cellular …