Glioblastoma multiforme (GBM), a grade IV astrocytoma, is the most common and deadly
type of primary malignant brain tumor, with a patient's median survival rate ranging from 15 …

Intratumoral fibrosis results from the deposition of a cross-linked collagen matrix by cancer-
associated fibroblasts (CAFs). This type of fibrosis has been shown to exert mechanical …

Background The epigenetic regulatory chemical lactate is a product of glycolysis. It can
regulate gene expression through histone lactylation, thereby promoting tumor proliferation …

Pathological remodeling of the extracellular matrix (ECM) by activated myofibroblasts is a
hallmark of fibrotic diseases and desmoplastic tumors. Activation of myofibroblasts occurs in …

Background: Hepatocellular carcinoma (HCC) is the world's second most deadly cancer,
and metabolic reprogramming is its distinguishing feature. Among metabolite profiling …

Background Adipocytes make up the major component of breast tissue, accounting for 90%
of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a …

Abstract Procollagen lysyl hydroxylase 1 (PLOD1) is highly expressed in malignant tumors
such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer …

Summary N 6-methyladenosine (m 6 A) plays crucial roles in regulating RNA metabolisms.
METTL16 identified as a single-component methyltransferase catalyzes m 6 A formation in …

Changes to extracellular matrix (ECM) structures are linked to tumor cell proliferation and
metastasis. We previously reported that naturally occurring peptides of collagen type I are …

Intratumoral hypoxia correlates with metastasis and poor survival in patients with sarcoma.
Using an impedance sensing assay and a zebrafish intravital microinjection model, we …