Bile acids and the gut microbiota: metabolic interactions and impacts on disease

SL Collins, JG Stine, JE Bisanz, CD Okafor… - Nature Reviews …, 2023 - nature.com
Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

The gut microbiome as a modulator of healthy ageing

TS Ghosh, F Shanahan, PW O'Toole - … Reviews Gastroenterology & …, 2022 - nature.com
The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

Obesity and type 2 diabetes mellitus: connections in epidemiology, pathogenesis, and treatments

R Ruze, T Liu, X Zou, J Song, Y Chen, R Xu… - Frontiers in …, 2023 - frontiersin.org
The prevalence of obesity and diabetes mellitus (DM) has been consistently increasing
worldwide. Sharing powerful genetic and environmental features in their pathogenesis …

Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome

Y Kawano, M Edwards, Y Huang, AM Bilate, LP Araujo… - Cell, 2022 - cell.com
How intestinal microbes regulate metabolic syndrome is incompletely understood. We show
that intestinal microbiota protects against development of obesity, metabolic syndrome, and …

Prevotella diversity, niches and interactions with the human host

A Tett, E Pasolli, G Masetti, D Ercolini… - Nature Reviews …, 2021 - nature.com
The genus Prevotella includes more than 50 characterized species that occur in varied
natural habitats, although most Prevotella spp. are associated with humans. In the human …

Gut microbial carbohydrate metabolism contributes to insulin resistance

T Takeuchi, T Kubota, Y Nakanishi, H Tsugawa… - Nature, 2023 - nature.com
Insulin resistance is the primary pathophysiology underlying metabolic syndrome and type 2
diabetes,. Previous metagenomic studies have described the characteristics of gut …

Gut microbiota-derived metabolites as central regulators in metabolic disorders

A Agus, K Clément, H Sokol - Gut, 2021 - gut.bmj.com
Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

[HTML][HTML] The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice

Y Fan, RK Støving, S Berreira Ibraim… - Nature …, 2023 - nature.com
Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are
women and it has a population prevalence of about 1%, but evidence-based treatment is …

Gut microbiota in human metabolic health and disease

Y Fan, O Pedersen - Nature Reviews Microbiology, 2021 - nature.com
Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

Gut microbial metabolites as multi-kingdom intermediates

KA Krautkramer, J Fan, F Bäckhed - Nature Reviews Microbiology, 2021 - nature.com
The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …