Biosynthesis and synthetic biology of psychoactive natural products

CS Jamieson, J Misa, Y Tang… - Chemical Society Reviews, 2021 - pubs.rsc.org
Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

Diversity, biology, and history of psilocybin-containing fungi: suggestions for research and technological development

RC Van Court, MS Wiseman, KW Meyer, DJ Ballhorn… - Fungal Biology, 2022 - Elsevier
Therapeutic use of psilocybin has become a focus of recent international research, with
preliminary data showing promise to address a range of treatment-resistant mental health …

Genera of Inocybaceae: New skin for the old ceremony

PB Matheny, AM Hobbs, F Esteve-Raventós - Mycologia, 2020 - Taylor & Francis
ABSTRACT A six-gene phylogeny of the Inocybaceae is presented to address classification
of major clades within the family. Seven genera are recognized that establish a global …

[HTML][HTML] Seeking the Psilocybiome: Psychedelics meet the microbiota-gut-brain axis

JR Kelly, G Clarke, A Harkin, SC Corr, S Galvin… - International Journal of …, 2023 - Elsevier
Moving towards a systems psychiatry paradigm embraces the inherent complex interactions
across all levels from micro to macro and necessitates an integrated approach to treatment …

Psychoactive plant-and mushroom-associated alkaloids from two behavior modifying cicada pathogens

GR Boyce, E Gluck-Thaler, JC Slot, JE Stajich… - Fungal Ecology, 2019 - Elsevier
Entomopathogenic fungi routinely kill their hosts before releasing infectious spores, but a
few species keep insects alive while sporulating, which enhances dispersal. Transcriptomics …

Phylogenomics of the psychoactive mushroom genus Psilocybe and evolution of the psilocybin biosynthetic gene cluster

AJ Bradshaw, V Ramírez-Cruz… - Proceedings of the …, 2024 - National Acad Sciences
Psychoactive mushrooms in the genus Psilocybe have immense cultural value and have
been used for centuries in Mesoamerica. Despite the recent surge of interest in these …

Taking Different Roads: l‐Tryptophan as the Origin of Psilocybe Natural Products

C Lenz, A Sherwood, R Kargbo… - ChemPlusChem, 2021 - Wiley Online Library
Psychotropic fungi of the genus Psilocybe, colloquially referred to as „magic mushrooms”,
are best known for their l‐tryptophan‐derived major natural product, psilocybin. Yet, recent …

Potential benefits and harms: A review of poisonous mushrooms in the world

MQ He, MQ Wang, ZH Chen, WQ Deng, TH Li… - Fungal Biology …, 2022 - Elsevier
Mushrooms have long been considered as delicacies as well as used as important dietary
supplements and food. However, there are major concerns with poisonous mushrooms as …

Monoamine biosynthesis via a noncanonical calcium-activatable aromatic amino acid decarboxylase in psilocybin mushroom

MP Torrens-Spence, CT Liu, T Pluskal… - ACS chemical …, 2018 - ACS Publications
Aromatic l-amino acid decarboxylases (AAADs) are a phylogenetically diverse group of
enzymes responsible for the decarboxylation of aromatic amino acid substrates into their …

DNA Authentication and Chemical Analysis of Psilocybe Mushrooms Reveal Widespread Misdeterminations in Fungaria and Inconsistencies in Metabolites

AJ Bradshaw, TA Backman… - Applied and …, 2022 - Am Soc Microbiol
The mushroom genus Psilocybe is best known as the core group of psychoactive
mushrooms, yet basic information on their diversity, taxonomy, chemistry, and general …