Polypharmacology: drug discovery for the future

AS Reddy, S Zhang - Expert review of clinical pharmacology, 2013 - Taylor & Francis
In recent years, even with remarkable scientific advancements and a significant increase of
global research and development spending, drugs are frequently withdrawn from markets …

Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders

MR Herbert - Current opinion in neurology, 2010 - journals.lww.com
Contributions of the environment and environmentally vulnera... : Current Opinion in Neurology
Contributions of the environment and environmentally vulnerable physiology to autism spectrum …

Comparative toxicogenomics database (CTD): update 2021

AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2021 - academic.oup.com
Abstract The public Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is an
innovative digital ecosystem that relates toxicological information for chemicals, genes …

Predicting drug–disease associations through layer attention graph convolutional network

Z Yu, F Huang, X Zhao, W Xiao… - Briefings in …, 2021 - academic.oup.com
Background: Determining drug–disease associations is an integral part in the process of
drug development. However, the identification of drug–disease associations through wet …

The comparative toxicogenomics database: update 2019

AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is a premier
public resource for literature-based, manually curated associations between chemicals …

[HTML][HTML] BioCreative V CDR task corpus: a resource for chemical disease relation extraction

J Li, Y Sun, RJ Johnson, D Sciaky, CH Wei… - Database, 2016 - academic.oup.com
Community-run, formal evaluations and manually annotated text corpora are critically
important for advancing biomedical text-mining research. Recently in BioCreative V, a new …

Reactome: a database of reactions, pathways and biological processes

D Croft, G O'kelly, G Wu, R Haw… - Nucleic acids …, 2010 - academic.oup.com
Abstract Reactome (http://www. reactome. org) is a collaboration among groups at the
Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University …

Predicting drug-disease associations by using similarity constrained matrix factorization

W Zhang, X Yue, W Lin, W Wu, R Liu, F Huang, F Liu - BMC bioinformatics, 2018 - Springer
Background Drug-disease associations provide important information for the drug discovery.
Wet experiments that identify drug-disease associations are time-consuming and expensive …

The Comparative Toxicogenomics Database's 10th year anniversary: update 2015

AP Davis, CJ Grondin, K Lennon-Hopkins… - Nucleic acids …, 2015 - academic.oup.com
Ten years ago, the Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) was
developed out of a need to formalize, harmonize and centralize the information on …

The comparative toxicogenomics database: update 2013

AP Davis, CG Murphy, R Johnson, JM Lay… - Nucleic acids …, 2013 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) provides
information about interactions between environmental chemicals and gene products and …