[HTML][HTML] 9S1R nullomer peptide induces mitochondrial pathology, metabolic suppression, and enhanced immune cell infiltration, in triple-negative breast cancer …
Nullomers are the shortest strings of absent amino acid (aa) sequences in a species or
group of species. Primes are those nullomers that have not been detected in the genome of …
group of species. Primes are those nullomers that have not been detected in the genome of …
[HTML][HTML] Peptide absent sequences emerging in human cancers
Early diagnosis of cancer can significantly improve survival of cancer patients; however
sensitive and highly specific biomarkers for cancer detection are currently lacking for most …
sensitive and highly specific biomarkers for cancer detection are currently lacking for most …
High content analysis technology for evaluating the joint toxicity of sunset yellow and sodium sulfite in vitro
D Qu, Y Gu, L Feng, J Han - Food chemistry, 2017 - Elsevier
Foods contain various additives that affect our daily lives. At present, food additive safety
evaluation standards are based on the toxicity of single additives, but food additives are …
evaluation standards are based on the toxicity of single additives, but food additives are …
Significant non-existence of sequences in genomes and proteomes
G Koulouras, MC Frith - Nucleic acids research, 2021 - academic.oup.com
Minimal absent words (MAWs) are minimal-length oligomers absent from a genome or
proteome. Although some artificially synthesized MAWs have deleterious effects, there is still …
proteome. Although some artificially synthesized MAWs have deleterious effects, there is still …
[HTML][HTML] kmerDB: a database encompassing the set of genomic and proteomic sequence information for each species
The decrease in sequencing expenses has facilitated the creation of reference genomes
and proteomes for an expanding array of organisms. Nevertheless, no established …
and proteomes for an expanding array of organisms. Nevertheless, no established …
[HTML][HTML] Absent from DNA and protein: genomic characterization of nullomers and nullpeptides across functional categories and evolution
I Georgakopoulos-Soares, O Yizhar-Barnea… - Genome biology, 2021 - Springer
Nullomers and nullpeptides are short DNA or amino acid sequences that are absent from a
genome or proteome, respectively. One potential cause for their absence could be their …
genome or proteome, respectively. One potential cause for their absence could be their …
Tools to measure cell health and cytotoxicity using high content imaging and analysis
BS Mandavilli, RJ Aggeler, KM Chambers - High Content Screening: A …, 2018 - Springer
High content screening (HCS)-based multiparametric measurements are very useful in early
toxicity testing and safety assessment during drug development, and useful in evaluating the …
toxicity testing and safety assessment during drug development, and useful in evaluating the …
[HTML][HTML] Nullomers and high order nullomers in genomic sequences
A nullomer is an oligomer that does not occur as a subsequence in a given DNA sequence,
ie it is an absent word of that sequence. The importance of nullomers in several applications …
ie it is an absent word of that sequence. The importance of nullomers in several applications …
[HTML][HTML] The effect of Nullomer-derived peptides 9R, 9S1R and 124R on the NCI-60 panel and normal cell lines
A Alileche, G Hampikian - BMC cancer, 2017 - Springer
Background Nullomer peptides are the smallest sequences absent from databases of
natural proteins. We first began compiling a list of absent 5-amino acid strings in 2006 (1) …
natural proteins. We first began compiling a list of absent 5-amino acid strings in 2006 (1) …
[HTML][HTML] The farther the better: Investigating how distance from human self affects the propensity of a peptide to be presented on cell surface by MHC class I molecules …
More than twenty years ago the reverse vaccinology paradigm came to light trying to design
new vaccines based on the analysis of genomic information in order to select those …
new vaccines based on the analysis of genomic information in order to select those …