Summary LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …

Melanoma is the leading cause of global skin cancer-related death and currently ranks as
the third most commonly diagnosed cancer in Australia. Melanoma patients with in-transit …

A large number of studies indicate that Potassium Voltage-Gated Channel Q4 (KCNQ4)
gene is the cause of non-syndromic hearing loss, but there are few studies investigating the …

Research on the mechanism and application of checkpoint inhibitory receptors in
hematologic diseases has progressed rapidly. However, in the treatment of relapserefractory …

Simple Summary Antibody–drug conjugates (ADCs) and immune checkpoint inhibitors (ICIs)
are two promising therapeutic modalities against many types of cancers. However, many …

Cell-cell junctions formed by the association of cell adhesion molecules facilitate
physiological events necessary for growth and development of multicellular organisms …

Simple Summary One-fifth of patients with advanced testicular germ cell tumors (TGCTs)
develop platinum-refractory disease. Recent advances in the use of immunotherapy in solid …

The combination of pembrolizumab and enfortumab vedotin shows promise as a first-line
therapy for advanced urothelial carcinoma. Enfortumab vedotin targets nectin-4, in turn …

Abstract CRTAM (Class-I MHC restricted T cell-associated molecule) is a member of the
Nectin-like family, composed of two extracellular domains, one constant domain (IgC) and …

Adherens junction is a multiprotein junctional complex that establishes cell-to-cell
adherence and regulates important biological events like early developmental processes …