Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for
triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

Type 1 diabetes (T1D) is a chronic autoimmune disease in which destruction or damaging of
the beta-cells in the islets of Langerhans results in insulin deficiency and hyperglycemia. We …

Cellular senescence is thought to contribute to age-associated deterioration of tissue
physiology. The senescence effector p16Ink4a is expressed in pancreatic beta cells during …

Replenishing insulin-producing pancreatic b cell mass will benefit both type I and type II
diabetics. In adults, pancreatic b cells are generated primarily by self-duplication. We report …

Diabetes is the result of having inadequate supply of functional insulin-producing β cells.
Two possible approaches for replenishing the β cells are:(1) replacement by transplanting …

Pancreatic insulin-producing β-cells have a long lifespan, such that in healthy conditions
they replicate little during a lifetime. Nevertheless, they show increased self-duplication after …

An important unresolved question in skeletal muscle plasticity is whether satellite cells are
necessary for muscle fiber hypertrophy. To address this issue, a novel mouse strain (Pax7 …

Intraportal islet transplantation has proven to be efficacious in preventing severe
hypoglycemia and restoring insulin independence in selected patients with type 1 diabetes …

The seemingly inexorable decline in insulin independence after islet transplant alone (ITA)
has raised concern about its clinical utility. We hypothesized that induction …