Toxic epidermal necrolysis (TEN) is an unpredictable, life-threatening drug reaction
associated with a 30% mortality. Massive keratinocyte apoptosis is the hallmark of TEN …

Background Allopurinol is the primary therapy for the management of chronic gout.
Utilization of allopurinol has increased in tandem with the growing prevalence of gout …

Background: Gout is a common type of inflammatory arthritis in patients seen by primary
care physicians. Purpose: To review evidence about treatment of acute gout attacks …

Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic
symptoms (DRESS) is a life-threatening adverse reaction characterized by skin rashes …

Objectives: To investigate the efficacy and tolerability of allopurinol as the first-choice
antihyperuricaemic treatment for gout, and compare the efficacy and tolerability of …

Drug-induced hypersensitivity syndrome (DIHS) is a life-threatening adverse systemic
reaction characterized by skin rashes, fever, leukocytosis with eosinophilia and/or atypical …

The methanol extract of the stem of Sinofranchetia chinensis inhibited the activity of xanthine
oxidase in vitro. Bioassay-guided purification led to the isolation of liquiritigenin and …

Clinically, erythema multiforme involves macular, papular or urticarial lesions, as well as the
classical iris or 'target lesions', distributed preferentially on the distal extremities. Lesions …

Discussion Raised serum urate concentrations have been associated with insulin
resistance, obesity, hypertension, dyslipidemia, and atherosclerotic disease. For this reason …

The mortality rate of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis
(TEN) is high; approximately 5% for SJS and 25% for TEN. It is therefore vital for the treating …