Glial progenitor heterogeneity and key regulators revealed by single-cell RNA sequencing provide insight to regeneration in spinal cord injury

H Wei, X Wu, J Withrow, RCD Duran, S Singh… - Cell reports, 2023 - cell.com
Recent studies have revealed the heterogeneous nature of astrocytes; however, how
diverse constituents of astrocyte-lineage cells are regulated in adult spinal cord after injury …

Transcriptional profiles of non-neuronal and immune cells in mouse trigeminal ganglia

J Mecklenburg, SA Shein, M Malmir… - Frontiers in Pain …, 2023 - frontiersin.org
Non-neuronal cells constitute 90%–95% of sensory ganglia. These cells, especially glial
and immune cells, play critical roles in the modulation of sensory neurons. This study aimed …

Spatially Aware Domain Adaptation Enables Cell Type Deconvolution from Multi‐Modal Spatially Resolved Transcriptomics

L Wang, X Bai, C Zhang, Q Shi, L Chen - Small Methods, 2024 - Wiley Online Library
Abstract Spatially Resolved Transcriptomics (SRT) offers unprecedented opportunities to
elucidate the cellular arrangements within tissues. Nevertheless, the absence of …

Uncovering oligodendrocyte enhancers that control Cnp expression

C Fan, H An, D Kim, Y Park - Human molecular genetics, 2023 - academic.oup.com
Oligodendrocytes (OLs) produce myelin sheaths around axons in the central nervous
system (CNS). Myelin accelerates the propagation of action potentials along axons and …

SRT-Server: powering the analysis of spatial transcriptomic data

S Yang, X Zhou - Genome Medicine, 2024 - Springer
Background Spatial resolved transcriptomics (SRT) encompasses a rapidly developing set
of technologies that enable the measurement of gene expression in tissue while retaining …

[HTML][HTML] Single-cell and spatial omics: exploring hypothalamic heterogeneity

M Junaid, EJ Lee, SB Lim - Neural Regeneration Research, 2025 - journals.lww.com
Elucidating the complex dynamic cellular organization in the hypothalamus is critical for
understanding its role in coordinating fundamental body functions. Over the past decade …

Identifying an oligodendrocyte enhancer that regulates Olig2 expression

C Fan, D Kim, H An, Y Park - Human molecular genetics, 2023 - academic.oup.com
Olig2 is a basic helix–loop–helix transcription factor that plays a critical role in the central
nervous system. It directs the specification of motor neurons and oligodendrocyte precursor …

Locus coeruleus vulnerability to tau hyperphosphorylation in a rat model

T Omoluabi, Z Hasan, JE Piche, ARS Flynn… - Aging …, 2024 - Wiley Online Library
Post‐mortem investigations indicate that the locus coeruleus (LC) is the initial site of
hyperphosphorylated pretangle tau, a precursor to neurofibrillary tangles (NFTs) found in …

Functional investigation of SLC1A2 variants associated with epilepsy

Q Qu, W Zhang, J Wang, D Mai, S Ren, S Qu… - Cell Death & …, 2022 - nature.com
Epilepsy is a common neurological disorder and glutamate excitotoxicity plays a key role in
epileptic pathogenesis. Astrocytic glutamate transporter GLT-1 is responsible for preventing …

Single-cell sequencing reveals glial cell involvement in development of neuropathic pain via myelin sheath lesion formation in the spinal cord

D Li, K Yang, J Li, X Xu, L Gong, S Yue, H Wei… - Journal of …, 2024 - Springer
Background Neuropathic pain (NP), which results from injury or lesion of the somatosensory
nervous system, is intimately associated with glial cells. The roles of microglia and …